Seasonal Allergic Rhinitis: Fexo” Tablets are indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 6 years of age and older. Fexo Oral Suspension is indicated for the relief of symptoms associated with seasonal allergic rhinitis in children 2 to 11 years of age. Symptoms to treat effectively: sneezing, rhinorrhea, itchy nose/palate/throat, itchy/watery/red eyes. Chronic Idiopathic Urticaria: Fexo Tablets are indicated for treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 years of age and older. Fexo Oral Suspension is indicated for treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in children 6 months to 11 years of age. Fexofenadine Hydrochloride significantly reduces pruritus and the number of wheals.
Fexofenadine Hydrochloride is an antihistamine with selective peripheral H, -receptor antagonist activity. Fexofenadine is rapidly absorbed after oral doses with peak plasma concentrations being reached in 2-3 hours. It is about 60 to 70% bound to plasma proteins. About 5% of the total doses is metabolized, mostly by the intestinal mucosa, with only 0.5 to 1.5% of the dose undergoing hepatic biotransformation by the cyto-chrome P450 system. Elimination half-life of 14 hours has been reported although this may be prolonged in patients with renal impairment. Excretion is mainly in the faeces with only 10% being present in the urine. Fexofenadine does not appear to cross the blood-brain barrier.
Dosage guidelines for different formulations of Paracetamol are as follows:
Fexofenadine is contraindicated in patients with known hypersensitivity to any of the ingredients.
Hepatic processes cannot be used to interact with other drugs since fexofenadine does not undergo hepatic biotransformation. The plasma concentration of fexofenadine is shown to rise 2- to 3-fold when erythromycin or ketoconazole are taken along with 120 mg of Fexo. The QT interval was unaffected by the changes, and there was no subsequent rise in adverse effects when compared with the drug administered alone. No evidence was found to suggest a relationship between omeprazole and fexofenadine. Unfortunately, the bioavailability of Fexo 120 mg was shown to be reduced when taken fifteen minutes before to taking an antacid that included aluminum and magnesium hydroxide gels. This was likely due to binding in the gastrointestinal system. Antacids containing aluminum or magnesium hydroxide should be taken at least two hours apart from the administration of Fexo 120 mg.
This frequency rating has been used where it is appropriate: Very common: 1/10,000; very rare: 1/10,000; common: 1/100; uncommon: 1/1,000; and Frequency cannot be calculated using the supplied data; hence, the value is unknown, at 1/1,000. Within each frequency category, the unwanted consequences are enumerated in decreasing order of importance. Clinical investigations have demonstrated the following detrimental effects in adults, with a frequency equivalent to that reported with a placebo: Common nervous system ailments include headaches, tiredness, and vertigo. Frequent gastrointestinal concerns include nausea, coupled with general troubles and issues with the administration site. – Unusual: fatigue. The following unfavorable outcomes have been documented in post-marketing monitoring in adults. They do not occur often and their frequency cannot be approximated from the data presently available. Immune system problems, including hypersensitive reactions that include angioedema, tightness in the chest, dyspnea, flushing, and systemic anaphylaxis; Mental illnesses such as anxiety, nightmares, sleeplessness, or excessive dreaming (paroniria); cardiac issues such as palpitations and tachycardia; Diarrhea as a gastrointestinal condition; Disorders of the skin and subcutaneous tissues: rash, urticaria, and pruritus.
Fexo 120 mg is under category C by the US FDA during pregnancy. Therefore, it is advisable to avoid taking Fexo 120 mg during pregnancy and nursing unless the benefits to one exceed the dangers to the baby.
Medicine should only be prescribed by a registered physician. Store below 30°C. Protect from light. Keep out of the reach of children.
Fexo 60: Each box contains 50 tablets in a blister pack. Fexo 120: Each box contains 50 tablets in a blister pack. Fexo 180: Each box contains 30 tablets in a blister pack. Fexo Suspension: Each bottle contains 50 ml suspension and measuring ex.